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What
is REDIARC?
The Retinal Disease Image Analysis Reading Center is an independently funded
research subunit of the Center for Visual Sciences,
Department of Ophthalmology at Case Western Reserve University located at the University
Hospitals Case Medical Center. Dr. Suber Huang serves as Principal Investigator for REDIARC, in addition to serving as Professor and Vice-Chairman of
Ophthalmology at CASE, Director of Vitreoretinal Diseases
and Surgery at University Hospitals Case Medical Center and Director of Ophthalmology Clinical Research. Conceived
in 2000, REDIARC currently serves as a Reading Center
for masked analysis of imaging data obtained in prospective,
multi-center, clinical trials. Data is used to evaluate
the safety, efficacy, or progression of retinal diseases
as documented by retinal fundus and/or fluorescein angiographic
imaging of the retinal vasculature. REDIARC has the capability to analyze both film and digital data.
Current
research -
This section is currently being updated.
Previous projects include four asynchronous
studies of the safety and efficacy of fluocinolone acetonide
delivered by a unique intravitreal delivery device (Envison
TD, patented, Bausch and Lomb) in the treatment of non-infectious
ocular inflammatory disease (uveitis). A separate study
also assesses the use of this device for the treatment
of unresponsive diabetic macular edema as a cause of
chronic visual loss. Other studies include the evaluation
of retinal vascular changes in Alzheimer’s disease
in affected patients, unaffected siblings, and in an
age-matched cohort. REDIARC also serves as the designated
data analysis center for the APEX 2003 expedition, a
multidisciplinary study of the effects of severe altitude
on the retina conducted in the Bolivian Andes. Together,
REDIARC currently expects to analyze 500,000 images
from 128 clinical sites located in 23 countries over
a 6 year period.
Capabilities -
REDIARC seeks to continue to provide objective masked
data analysis for clinical studies. REDIARC intends
to use telemedicine and remote diagnostic capabilities
to study diabetic retinopathy. REDIARC-funded database
research using Markovian modeling has produced a more
efficient algorithm for screening. It is hoped that
a strategy for widespread screening of diabetic complications
can be profitably utilized to prevent blinding complications
in the uninsured and under-insured. Effective utilization
of resources has significant consequences for developing
a world-wide, international screening strategy.
In partnership with the Specular Microscopy Reading Center at University Hospitals Case Medical Center and the OCT Reading Center at Duke University, REDIARC actively seeks engagement in other clinical studies including: Macular Degeneration, Diabetes, Glaucoma, and Corneal Diseases.
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